At Nuon Medical, we reimagine skincare delivery as an intelligent, engineered system—one that adapts to individual skin needs through technology, not guesswork. As consumer expectations shift toward customization and clinically proven results, formulation alone is no longer enough. How active ingredients are delivered is now just as critical as what they are.
We integrate proven delivery technologies into tailored applicator systems that enhance efficacy, absorption, and user satisfaction. From wrinkle reduction and barrier support to collagen stimulation and targeted brightening, our personalized skincare technology enables beauty brands to offer visible results—without changing the original formula.
Each system is developed with precision, grounded in dermatological research and clinical validation. Our work goes beyond product development. We lead with insight, translating complex scientific mechanisms into scalable solutions that meet today’s diverse consumer needs.
In this blog, we spotlight two of today’s highest-performing cosmetic technologies that power Nuon Medical's personalized delivery systems:
Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles [Read Here]
At a glance:
- Randomized Clinical Trial | 42 Women | 8 Weeks | 2017
- Results: “We found that combining the massaging device with a skin anti-aging formulation amplified the beneficial effects of the cream.”
- Published in journal: Public Library of Science
Mechanical and geometrical cues influence cell behaviour. At the tissue level, almost all organs exhibit immediate mechanical responsiveness, in particular by increasing their stiffness in direct proportion to an applied mechanical stress. It was recently shown in cultured-cell models, in particular with fibroblasts, that the frequency of the applied stress is a fundamental stimulating parameter. However, the influence of the stimulus frequency at the tissue level has remained elusive. Using a device to deliver an oscillating torque that generates cyclic strain at different frequencies, we studied the effect(s) of mild skin massage in an ex vivo model and in vivo. Skin explants were maintained ex vivo for 10 days and massaged twice daily for one minute at various frequencies within the range of 65–85 Hz. Biopsies were analysed at D0, D5 and D10 and processed for immuno-histological staining specific to various dermal proteins. As compared to untreated skin explants, the massaging procedure clearly led to higher rates of expression, in particular for decorin, fibrillin, tropoelastin, and procollagen-1. The mechanical stimulus thus evoked an anti-aging response. Strikingly, the expression was found to depend on the stimulus frequency with maximum expression at 75Hz. We then tested whether this mechanical stimulus had an anti-aging effect in vivo. Twenty Caucasian women (aged 65-75y) applied a commercial anti-aging cream to the face and neck, followed by daily treatments using the anti-aging massage device for 8 weeks. A control group of twenty-two women, with similar ages to the first group, applied the cream alone. At W0, W4 and W8, a blinded evaluator assessed the global facial wrinkles, skin texture, lip area, cheek wrinkles, neck sagging and neck texture using a clinical grading scale. We found that combining the massaging device with a skin anti-aging formulation amplified the beneficial effects of the cream.
The addition of vibrational stimulation to the skin is proven to boost the anti-aging effect of skin cream compared to that of cream alone. This important takeaway is a key insight in boosting the aesthetic outcome of customers seeking more youthful skin; beyond that which cream alone can offer. While creams can provide a meaningful benefit, vibrational massage stimulation improves absorption and overall outcomes. Nuon makes this pair seamless, incorporating vibrational stimulation into the very applicator that your customers already use to deliver the cream.
Even a short one-minute use daily, during skin care application, is shown to improve positive effects. We read: “When the stimulation protocol is repeated twice per day, the effect is observed even when the stimulus is applied for short durations (1 min).”
The paper concludes “Such dynamic mechanical stimulation leads to amplification, in vivo, of the anti-wrinkle effect provided by the regular use of an anti-aging cosmetic regimen. Hence, with a device that delivers properly tuned stimuli, skin massaging provides an efficient anti-aging strategy.
This exciting frontier in skincare technologies is made easy with Nuon’s C.U.R.V.E model, helping you go from concept to final product without friction.
Visual Analogy: Skin Absorption
Watch [1:27] Sand liquefied
Video Description
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Our skin behaves like a firm bed of sand, preventing the ball from sinking beneath the surface, even with a strong push of the hand. However, once the sand is thrown into proper vibration and aeration, it becomes nearly fluidic allowing the ball to be easily submerged beneath the surface.
We can use this analogy to discuss how vibrational technologies improve the absorption of skin cream. The ball is likened to the cream on the surface of our skin (the sand). When we first apply a cream, our skin behaves like a dense shield, preventing the cream from reaching deeper into our skin’s layers. However, once we introduce a vibrational effect, whether through TENS or mechanical stimulation, the skin is much more receptive to absorption, boosting the ease & depth to which the cream is absorbed.
Looking to get the best results out of your skin application products?
Nuon makes it easy to boost absorption and skin hydration with integrated vibrational technologies.
At a glance:
- Randomized Clinical Trial | 137 Participants | 4 Weeks | 2023
- Results: There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM.
- Published in journal: Photobiomodulation, Photomedicine, and Laser Surgery
Objective: This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose.
Background: The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. In vitro red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis. Meanwhile, red PBM has already been studied in clinical trials; however, a comparison of the use of different wavelengths at the same light dose to reduce periocular wrinkles has not yet been performed.
Methods: This split-face, randomized clinical trial recruited 137 women (40-65 years old) presenting with skin phototypes II-IV and Glogau photoaging scale types II-IV. The individuals received 10 sessions for 4 weeks of red (660 nm) and amber (590 nm) PBM (3.8 J/cm2), one at each side of the face.
Results: There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM. None of the treatments improved skin hydration and viscoelasticity. Both questionnaires showed improvements in participants' quality of life.
Conclusions: PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction.
Our featured study, Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial, demonstrates the exceptional results that light therapy can provide in reducing wrinkles. The mechanisms of action can be difficult to comprehend when written in clinical trial language, so we will discuss simplified, but still scientifically accurate, models below.
The health of our skin depends on maintaining healthy skin cells.
We can boost skin health by: (1) Improving our nutrients and (2) Reducing our toxins.
Improving Nutrients: Each cell in our body requires optimal levels of blood circulation and mitochondrial energy (ATP) to maintain a healthy and youthful state. Throughout our lifetime spent aging, our body’s ability to circulate blood and maintain proper mitochondrial respiration (energy production) slows. These essential processes can be boosted through the application of red & near-infrared light, much like how a solar panel improves in electrical energy when the quantity of sunlight it is exposed to increases.
Reducing Toxins: Additionally, as we age, our skin cells begin to suffer damage from accumulated oxidative stress. This oxidative stress inside the body is similar to how a metal rusts outside; the shiny and smooth surface of the metal loses its youthful sheen and degrades into flaky, weak, material. As our skin cells ‘rust’ from excessive oxidative stress, we begin to see wrinkles, pigmentation, and other aesthetic damage. We can reduce this ‘skin rust’ through the proper dosing of therapeutic light, much like how a powerful laser can remove the rust from a piece of metal.
Visual Analogy: Rust removal on metal
Rust & Removal: The rust is a layer of oxidized iron, or iron that has reacted with the water and air to become porous, flaky, and weak. This corrosion will continue to build up and reduce the strength of the material, unless removed. Through the application of a powerful laser, the rust can be instantly removed, restoring the shiny sheen of the metal.
Skin Analogy: Our skin builds up oxidative stress, much like the accumulation of rust on the metal. To remove these ‘rust molecules’ or ‘reactive oxygen species’ from our skin, we can shine Red & Near-Infrared Light onto the skin. The energy of the light causes a photodissociation reaction in the oxidative stress, reducing the accumulated toxin. Said more simply, the right type and dose of light causes the rust to dissipate, much like the laser removing rust in the video above.
Join us in our next blog as we discuss Transcutaneous Electrical Nerve Stimulation (TENS) and Pulsed Electromagnetic Fields (PEMF).
Looking to integrate personalized skincare technology into your next product?
Partner with Nuon Medical and take the next strategic step toward high-performance, tailored delivery systems.
Contact: info@NuonMedical.com
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